Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity
Само за регистроване кориснике
2017
Аутори
Šavikin, K.P.Krstić-Milošević, D.B.
Menković, N.R.
Beara, Ivana
Mrkonjić, Zorica
Pljevljakušić, D.S.
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, ...at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.
Кључне речи:
Reducing power / Radical scavenging / Phenolics / Hyperoside / Hawthorn / Anti-inflammatoryИзвор:
Natural Product Communications, 2017, 12, 2, 159-162Издавач:
- Natural Product Incorporation
Институција/група
Fakultet ekološke poljoprivredeTY - CONF AU - Šavikin, K.P. AU - Krstić-Milošević, D.B. AU - Menković, N.R. AU - Beara, Ivana AU - Mrkonjić, Zorica AU - Pljevljakušić, D.S. PY - 2017 UR - https://redun.educons.edu.rs/handle/123456789/309 AB - The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents. PB - Natural Product Incorporation C3 - Natural Product Communications T1 - Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity EP - 162 IS - 2 SP - 159 VL - 12 DO - 10.1177/1934578x1701200204 UR - conv_1179 ER -
@conference{ author = "Šavikin, K.P. and Krstić-Milošević, D.B. and Menković, N.R. and Beara, Ivana and Mrkonjić, Zorica and Pljevljakušić, D.S.", year = "2017", abstract = "The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.", publisher = "Natural Product Incorporation", journal = "Natural Product Communications", title = "Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity", pages = "162-159", number = "2", volume = "12", doi = "10.1177/1934578x1701200204", url = "conv_1179" }
Šavikin, K.P., Krstić-Milošević, D.B., Menković, N.R., Beara, I., Mrkonjić, Z.,& Pljevljakušić, D.S.. (2017). Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. in Natural Product Communications Natural Product Incorporation., 12(2), 159-162. https://doi.org/10.1177/1934578x1701200204 conv_1179
Šavikin K, Krstić-Milošević D, Menković N, Beara I, Mrkonjić Z, Pljevljakušić D. Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. in Natural Product Communications. 2017;12(2):159-162. doi:10.1177/1934578x1701200204 conv_1179 .
Šavikin, K.P., Krstić-Milošević, D.B., Menković, N.R., Beara, Ivana, Mrkonjić, Zorica, Pljevljakušić, D.S., "Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity" in Natural Product Communications, 12, no. 2 (2017):159-162, https://doi.org/10.1177/1934578x1701200204 ., conv_1179 .