Phytochemical composition and in vitro functional properties of three wild rose hips and their traditional preserves
AuthorsNadpal, Jelena D.
Majkić, Tatjana M.
Cetojević-Simin, Dragana D.
Article (Published version)
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The aim of the present study was investigation of the phenolic profile, ascorbic acid content, antioxidant, anti-acetylcholinesterase, anti-inflammatory and cytotoxic activity of rose hips and the preserves (puree and jam) of three insufficiently examined Rosa species: Rosa dumalis Bechst., R. dumetorum Thuill. and R. sempervirens L. The liquid chromatography-tandem mass spectrometry analysis resulted in quantification of 14 of the 45 phenolic compounds examined, with ellagic acid as the most dominant. Notable antioxidant activity of all three species was confirmed through several assays. Moderate inhibition of acetylcholinesterase by extracts of all investigated Rosa species was observed. Several extracts of examined Rosa species demonstrated inhibition potency towards production of some monitored eicosanoids in cyclooxygenase-1 and 12-lipoxygenase pathways. Two R. sempervirens extracts exerted cytotoxic activity against HeLa and HT-29 cell lines, but were inactive towards MRC-5 and M...CF7. The results support the potential of these rose hips as food with health-promoting properties.
Keywords:Rosa sempervirens L. / Rosa dumetorum Thuill / Rosa dumalis Bechst / LC-MS/MS / Cytotoxic activity / Antioxidant activity / Anti-inflammatory activity / Anti-acetylcholinesterase activity
Source:Food Chemistry, 2018, 241, 290-300
- ELSEVIER SCI LTD, OXFORD
Funding / projects:
- Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)